Pesquisa | BVS IEC

1.

Putting p53 in Context.

Kastenhuber, Edward R; Lowe, Scott W.

Cell ; 170(6): 1062-1078, 2017 Sep 07.

Artigo em Inglês | MEDLINE | ID: mdl-28886379

2.

PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer.

Bonavita, Eduardo; Gentile, Stefania; Rubino, Marcello; Maina, Virginia; Papait, Roberto; Kunderfranco, Paolo; Greco, Carolina; Feruglio, Francesca; Molgora, Martina; Laface, Ilaria; Tartari, Silvia; Doni, Andrea; Pasqualini, Fabio; Barbati, Elisa; Basso, Gianluca; Galdiero, Maria Rosaria; Nebuloni, Manuela; Roncalli, Massimo; Colombo, Piergiuseppe; Laghi, Luigi; Lambris, John D; Jaillon, Sébastien; Garlanda, Cecilia; Mantovani, Alberto.

Cell ; 160(4): 700-714, 2015 Feb 12.

Artigo em Inglês | MEDLINE | ID: mdl-25679762

3.

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.

Dow, Lukas E; O'Rourke, Kevin P; Simon, Janelle; Tschaharganeh, Darjus F; van Es, Johan H; Clevers, Hans; Lowe, Scott W.

Cell ; 161(7): 1539-1552, 2015 Jun 18.

Artigo em Inglês | MEDLINE | ID: mdl-26091037

4.

RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma.

Whittle, Martin C; Izeradjene, Kamel; Rani, P Geetha; Feng, Libing; Carlson, Markus A; DelGiorno, Kathleen E; Wood, Laura D; Goggins, Michael; Hruban, Ralph H; Chang, Amy E; Calses, Philamer; Thorsen, Shelley M; Hingorani, Sunil R.

Cell ; 161(6): 1345-60, 2015 Jun 04.

Artigo em Inglês | MEDLINE | ID: mdl-26004068

5.

Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma.

Robbiani, Davide F; Deroubaix, Stephanie; Feldhahn, Niklas; Oliveira, Thiago Y; Callen, Elsa; Wang, Qiao; Jankovic, Mila; Silva, Israel T; Rommel, Philipp C; Bosque, David; Eisenreich, Tom; Nussenzweig, André; Nussenzweig, Michel C.

Cell ; 162(4): 727-37, 2015 Aug 13.

Artigo em Inglês | MEDLINE | ID: mdl-26276629

6.

Synonymous mutations frequently act as driver mutations in human cancers.

Supek, Fran; Miñana, Belén; Valcárcel, Juan; Gabaldón, Toni; Lehner, Ben.

Cell ; 156(6): 1324-1335, 2014 Mar 13.

Artigo em Inglês | MEDLINE | ID: mdl-24630730

7.

Nonstochastic reprogramming from a privileged somatic cell state.

Guo, Shangqin; Zi, Xiaoyuan; Schulz, Vincent P; Cheng, Jijun; Zhong, Mei; Koochaki, Sebastian H J; Megyola, Cynthia M; Pan, Xinghua; Heydari, Kartoosh; Weissman, Sherman M; Gallagher, Patrick G; Krause, Diane S; Fan, Rong; Lu, Jun.

Cell ; 156(4): 649-62, 2014 Feb 13.

Artigo em Inglês | MEDLINE | ID: mdl-24486105

8.

Interferon-Îµ is a tumour suppressor and restricts ovarian cancer.

Marks, Zoe R C; Campbell, Nicole K; Mangan, Niamh E; Vandenberg, Cassandra J; Gearing, Linden J; Matthews, Antony Y; Gould, Jodee A; Tate, Michelle D; Wray-McCann, Georgie; Ying, Le; Rosli, Sarah; Brockwell, Natasha; Parker, Belinda S; Lim, San S; Bilandzic, Maree; Christie, Elizabeth L; Stephens, Andrew N; de Geus, Eveline; Wakefield, Matthew J; Ho, Gwo-Yaw; McNally, Orla; McNeish, Iain A; Bowtell, David D L; de Weerd, Nicole A; Scott, Clare L; Bourke, Nollaig M; Hertzog, Paul J.

Nature ; 620(7976): 1063-1070, 2023 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-37587335

9.

Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression.

Chan, Chia-Hsin; Morrow, John Kenneth; Li, Chien-Feng; Gao, Yuan; Jin, Guoxiang; Moten, Asad; Stagg, Loren J; Ladbury, John E; Cai, Zhen; Xu, Dazhi; Logothetis, Christopher J; Hung, Mien-Chie; Zhang, Shuxing; Lin, Hui-Kuan.

Cell ; 154(3): 556-68, 2013 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-23911321

10.

Ordered and deterministic cancer genome evolution after p53 loss.

Baslan, Timour; Morris, John P; Zhao, Zhen; Reyes, Jose; Ho, Yu-Jui; Tsanov, Kaloyan M; Bermeo, Jonathan; Tian, Sha; Zhang, Sean; Askan, Gokce; Yavas, Aslihan; Lecomte, Nicolas; Erakky, Amanda; Varghese, Anna M; Zhang, Amy; Kendall, Jude; Ghiban, Elena; Chorbadjiev, Lubomir; Wu, Jie; Dimitrova, Nevenka; Chadalavada, Kalyani; Nanjangud, Gouri J; Bandlamudi, Chaitanya; Gong, Yixiao; Donoghue, Mark T A; Socci, Nicholas D; Krasnitz, Alex; Notta, Faiyaz; Leach, Steve D; Iacobuzio-Donahue, Christine A; Lowe, Scott W.

Nature ; 608(7924): 795-802, 2022 08.

Artigo em Inglês | MEDLINE | ID: mdl-35978189

11.

Fundamental immune-oncogenicity trade-offs define driver mutation fitness.

Hoyos, David; Zappasodi, Roberta; Schulze, Isabell; Sethna, Zachary; de Andrade, Kelvin César; Bajorin, Dean F; Bandlamudi, Chaitanya; Callahan, Margaret K; Funt, Samuel A; Hadrup, Sine R; Holm, Jeppe S; Rosenberg, Jonathan E; Shah, Sohrab P; Vázquez-García, Ignacio; Weigelt, Britta; Wu, Michelle; Zamarin, Dmitriy; Campitelli, Laura F; Osborne, Edward J; Klinger, Mark; Robins, Harlan S; Khincha, Payal P; Savage, Sharon A; Balachandran, Vinod P; Wolchok, Jedd D; Hellmann, Matthew D; Merghoub, Taha; Levine, Arnold J; Luksza, Marta; Greenbaum, Benjamin D.

Nature ; 606(7912): 172-179, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35545680

12.

Transcriptional down-regulation of metabolic genes by Gdown1 ablation induces quiescent cell re-entry into the cell cycle.

Jishage, Miki; Ito, Keiichi; Chu, Chi-Shuen; Wang, Xiaoling; Yamaji, Masashi; Roeder, Robert G.

Genes Dev ; 34(11-12): 767-784, 2020 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-32381628

13.

Mosaic analysis with double markers reveals tumor cell of origin in glioma.

Liu, Chong; Sage, Jonathan C; Miller, Michael R; Verhaak, Roel G W; Hippenmeyer, Simon; Vogel, Hannes; Foreman, Oded; Bronson, Roderick T; Nishiyama, Akiko; Luo, Liqun; Zong, Hui.

Cell ; 146(2): 209-21, 2011 Jul 22.

Artigo em Inglês | MEDLINE | ID: mdl-21737130

14.

Phase and context shape the function of composite oncogenic mutations.

Gorelick, Alexander N; Sánchez-Rivera, Francisco J; Cai, Yanyan; Bielski, Craig M; Biederstedt, Evan; Jonsson, Philip; Richards, Allison L; Vasan, Neil; Penson, Alexander V; Friedman, Noah D; Ho, Yu-Jui; Baslan, Timour; Bandlamudi, Chaitanya; Scaltriti, Maurizio; Schultz, Nikolaus; Lowe, Scott W; Reznik, Ed; Taylor, Barry S.

Nature ; 582(7810): 100-103, 2020 06.

Artigo em Inglês | MEDLINE | ID: mdl-32461694

15.

Common activities and predictive gene signature identified for genetic hypomorphs of TP53.

Leung, Jessica C; Leu, Julia I-Ju; Indeglia, Alexandra; Kannan, Toshitha; Clarke, Nicole L; Kirven, Nicole A; Dweep, Harsh; Garlick, David; Barnoud, Thibaut; Kossenkov, Andrew V; George, Donna L; Murphy, Maureen E.

Proc Natl Acad Sci U S A ; 120(7): e2212940120, 2023 02 14.

Artigo em Inglês | MEDLINE | ID: mdl-36749725

16.

Triple-negative breast tumors are dependent on mutant p53 for growth and survival.

Dibra, Denada; Moyer, Sydney M; El-Naggar, Adel K; Qi, Yuan; Su, Xiaoping; Lozano, Guillermina.

Proc Natl Acad Sci U S A ; 120(34): e2308807120, 2023 08 22.

Artigo em Inglês | MEDLINE | ID: mdl-37579145

17.

p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cells.

Hassin, Ori; Sernik, Miriam; Seligman, Adi; Vogel, Felix C E; Wellenstein, Max D; Smollich, Joachim; Halperin, Coral; Pirona, Anna Chiara; Toledano, Liron Nomi; Caballero, Carolina Dehesa; Schlicker, Lisa; Salame, Tomer-Meir; Sarusi Portuguez, Avital; Aylon, Yael; Scherz-Shouval, Ruth; Geiger, Tamar; de Visser, Karin E; Schulze, Almut; Oren, Moshe.

Proc Natl Acad Sci U S A ; 120(52): e2311460120, 2023 Dec 26.

Artigo em Inglês | MEDLINE | ID: mdl-38127986

18.

Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α.

Basu, Subhasree; Gnanapradeepan, Keerthana; Barnoud, Thibaut; Kung, Che-Pei; Tavecchio, Michele; Scott, Jeremy; Watters, Andrea; Chen, Qing; Kossenkov, Andrew V; Murphy, Maureen E.

Genes Dev ; 32(3-4): 230-243, 2018 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-29463573

19.

The p53 network: cellular and systemic DNA damage responses in cancer and aging.

Vaddavalli, Pavana Lakshmi; Schumacher, Björn.

Trends Genet ; 38(6): 598-612, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35346511

20.

Disruption of the TP53 locus in osteosarcoma leads to TP53 promoter gene fusions and restoration of parts of the TP53 signalling pathway.

Saba, Karim H; Difilippo, Valeria; Kovac, Michal; Cornmark, Louise; Magnusson, Linda; Nilsson, Jenny; van den Bos, Hilda; Spierings, Diana Cj; Bidgoli, Mahtab; Jonson, Tord; Sumathi, Vaiyapuri P; Brosjö, Otte; Staaf, Johan; Foijer, Floris; Styring, Emelie; Nathrath, Michaela; Baumhoer, Daniel; Nord, Karolin H.

J Pathol ; 262(2): 147-160, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38010733

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Instituto Evandro Chagas

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